CD8 Encephalitis: A Diagnostic Dilemma
Diagnostics (Basel, Switzerland)
volume 12
issue 11
pages 2687
11/4/2022
Repository
Description
CD8+ encephalitis is a subacute encephalopathy associated with HIV infection. Pathophysiology is thought to be auto-reactive CD8+ cells attacking on HIV infected CD4+ cells and 'viral escape' phenomena (replication of CD8+ cells in CSF). We present a case of a 45-year-old man with well controlled HIV who developed CD8 encephalitis following Herpes simplex encephalitis. He had persistent encephalopathy for several weeks with status epilepticus and agitated delirium, and diagnosis remained elusive until a brain biopsy confirmed the diagnosis.
Affiliations
- College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
- College of Osteopathic Medicine, California Health Sciences University, Clovis, CA 93612, USA.
- Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
- Department of Neurocritical Care, Mayo Clinic in Florida, Jacksonville, FL 32224, USA.
- Department of Neurology, Baptist Medical Center, Jacksonville, FL 32207, USA.
- Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
- Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
- Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Publisher
MDPI AG