Relevance of epithelial-to-pericyte transition in cancer
Molecular & cellular oncology
volume 4
issue 1
pages e1260672
1/2/2017
Repository
Description
The relevance of epithelial-to-mesenchymal transition (EMT) in cancer is still under debate. Recently, we reported that EMT bestows key pericyte properties on cancer cells and may thus represent epithelial-to-pericyte transition (EPT). Carcinoma cells undergo EPT to stabilize blood vessels and fuel primary tumor growth. Association of EPT cancer cells with vascular niches may also promote resistance to therapy.
Affiliations
- Department of Biochemistry and Molecular Biology, University of Florida College of Medicine , Gainesville, FL, USA.
- Department of Pharmaceutics and Biomedical Sciences, California Health Sciences University , Clovis, CA, USA.
Publisher
Informa UK Limited