CHSU Discovery

Chemical characterization and evaluation of the nephroprotective potential of Parrotiopsis jacquemontiana (Decne) Rehder and Periploca hydaspidis Falc crude extract in CCl4-induced Male Sprague-Dawley Rats

Saudi journal of biological sciences Peer reviewed publication
volume 29 issue 2 pages 702-712
February 2021
DOI: 10.1016/j.sjbs.2021.09.057 PMID: 35197735
ISSN: 1319-562X EISSN: 2213-7106 KBID: 533529 LN: Hussain D CHSU: Faculty
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848011/
  2. https://pubmed.ncbi.nlm.nih.gov/35197735
  3. https://www.ncbi.nlm.nih.gov/pubmed/35197735
  4. https://doi.org/10.1016/j.sjbs.2021.09.057

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Biochemical, antioxidant, serum, and urine profiles together with physical examination can deliver important information regarding animal health status, and are vital in the diagnosis and treatment of patients. CCl4, a potent nephrotoxin, was used for causing toxicity in rat kidneys. The present study aimed at exploring the nephroprotective potential of P. jacquemontiana leaves methanol extract (PJM) and P. hydaspidis whole-plant methanol extract (PHM) on kidney cells of male rats after oxidative stress and DNA damage was instigated by CCl4. Various parameters including enzymatic levels, serum profiles, urine profiles, genotoxicity, and histological studies were conducted. In renal samples of rats treated with CCl4, the antioxidant enzymes (POD, SOD, CAT), PH level, protein level, and glutathione contents were significantly (p < 0.05) declined whereas renal biochemicals (H2O2, TBARS, and nitrite), specific gravity, level of urea, urobilinogen, serum BUN and creatinine were markedly (p < 0.05) increased relative to control group. Co-administration of PJM and PHM with CCl4 displayed protective ability against CCl4 intoxication by restoring activities of antioxidant enzymes, urine profile, biochemical parameters, and serum profile in rats. CCl4 also induced prominent DNA damages and glomerular atrophy with abnormal appearance of glomerulus and Bowman's capsule. These damages results in impaired corticular sections, edema in Bowman's capsule, accumulation of necrotic cells, dilation of convoluted tubules, and narrowing of space between Bowman's capsule, which were successfully ameliorated after co-administration of PJM and PHM fractions in a dose-dependent manner (200 and 400 mg/kg b.w.). The results obtained suggest the therapeutic role of PJM and PHM in oxidative-stress related disorders of kidney and may be helpful in kidney trauma.

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Subjects

Affiliations

  1. California Health Sciences University, College of Pharmacy, 120 N. Clovis Avenue, Clovis, CA 93612, United States
  2. Centre for Plant Science and Biodiversity, University of Swat, Kanju 19201, Pakistan
  3. Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan
  4. Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan
  5. Department of Botany, Bacha Khan University, Charsadda, Khyber Pakhtunkkhwa, Pakistan
  6. Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
  7. Department of Plant Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan
  8. University Institute of Biochemistry and Biotechnology, PMAS Arid Agriculture University Rawalpindi, Pakistan

Publisher

Elsevier (Saudi Arabia)

Languages

English

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