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Cureus 2023
Tracheomalacia (TM), the most common congenital tracheal defect, is due to compromised cartilage integrity, manifesting in the narrowing of expiratory airways and various respiratory symptoms. While TM is common in infants and toddlers, it is rarely…
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Journal of pharmaceutical sciences 2017
Lysine-proline-valine (KPV) is a C-terminal peptide fragment of α-melanocyte stimulating hormone with potent anti-inflammatory properties. Present study investigates various transdermal enhancement strategies such as iontophoresis (ITP), microneedle…
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Pain physician 2017
BACKGROUNDAbuse-deterrent formulations (ADFs) represent one novel strategy for curbing the potential of opioid abuse.OBJECTIVEWe aim to compare and contrast the characteristics and applications of current abuse-deterrent opioid products in clinical …
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PloS one 2021
Pueraria tuberosa (Roxb. ex Willd.) DC., known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy of an ethyl acetate fractio…
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Cureus 2023
We present the first documented case of metastatic melanoma to the orbit with dedifferentiation. A patient with a history of melanoma of the lip and other poorly differentiated carcinomas presented with both a sub-brow and an intraorbital mass. Radi…
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Hypertension (Dallas, Tex. : 1979) 2018
Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension
ArticlePulmonary hypertension (PH) is a devastating disease and its successful treatment remains to be accomplished despite recent advances in pharmacotherapy. It has been proposed that PH be considered as a systemic disease, rather than primarily a diseas…
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Journal of Patient Experience 2025
This study evaluated 4 leading Large Language Models’ (LLMs) (ChatGPT-o1, DeepSeek-v3, Gemini 2.0 Flash, and Claude 3.7 Sonnet) responses to a question about Diabetic Retinopathy. Methods: The following questions were posed to the 4 LLMS: “I am a 52…
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Currents in pharmacy teaching & learning 2021
BACKGROUND AND PURPOSETeam-based learning (TBL) and game-based learning (GBL) are evidence-based active learning pedagogies. This study reports a learning experience that harnesses TBL and GBL benefits by blending both pedagogies (referred herein as…
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Cureus 2022
Drug-induced pancreatitis (DIP), while not a major cause of acute pancreatitis, remains a debilitating diagnosis resulting in significant patient morbidity and mortality. The diagnosis includes first diagnosing acute pancreatitis, second ruling out …
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The European journal of neuroscience 2023
Current theories regarding accumulation of Alzheimer's disease-related deposits of abnormal intra- and extracellular proteins include reactions to inflammation and mitochondrial dysfunction. In this study, we explored whether age, genotype and infla…
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Orthopedic research and reviews 2023
Despite early reports of high failure rates in knee ligament repair techniques resulting in favor of reconstruction, newer advances in surgical technology have shifted the attention back to repair with the addition of various tissue augmentation tec…
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The Annals of pharmacotherapy 2024
BACKGROUNDFew studies have evaluated the administration of intravenous (IV) insulin infusions for uncontrolled hyperglycemia in non-intensive care unit (ICU) patients, and there is inadequate data to guide how to appropriately administer IV insulin …
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Biochemistry 2017
The Mycobacterium tuberculosis (Mtb) serine protease Hip1 (hydrolase important for pathogenesis; Rv2224c) promotes tuberculosis (TB) pathogenesis by impairing host immune responses through proteolysis of a protein substrate, Mtb GroEL2. The cell sur…
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Health services insights 2021
The opioid epidemic continues to be an ongoing public health crisis. Many primary health care providers aptly serve as the gatekeeper to opioid prescriptions. The opioid epidemic has challenged the primary care profession whilst many of these provid…
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Cureus 2025
Traumatic brain injury (TBI) remains a significant public health concern, particularly among military service members exposed to blast-related trauma. While mild TBIs often resolve within weeks, a subset of patients may experience lifelong, persiste…
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The American surgeon 2023
BACKGROUNDThe opioid crisis demands novel solutions for postoperative pain control. Traditional Chinese medicine (TCM) has used herbs for the treatment of pain for thousands of years. We studied whether a synergistic multimodal TCM supplement could …
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Cureus 2024
This review provides an in-depth analysis of the effect of length of stay (LOS), comorbidities, and procedural complications on the cost-effectiveness of transcatheter aortic valve replacement (TAVR) in comparison to surgical aortic valve replacemen…
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Currents in pharmacy teaching & learning 2018
BACKGROUND AND PURPOSEProject aim was to examine the feasibility and logistics of mentored self-directed learning (MSDL) through group and individual presentations in an accelerated modified block curriculum. Perspectives of students and faculty mem…
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Artificial cells, nanomedicine, and biotechnology 2018
In the present study, we have synthesized silver nanoparticles (AgNPs) using Pueraria tuberosa aqueous extract (PTAE) in a straightforward manner without involvement of toxic chemicals. Various reaction parameters (reaction time, AgNO3 concentration…
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The Annals of pharmacotherapy 2025
OBJECTIVESummarize the studies evaluating the use of subcutaneous (SQ) insulin in the management of diabetic ketoacidosis (DKA) in adults and pediatrics.DATA SOURCESA PubMed literature search was conducted for articles published between 2000 and the…
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