CHSU Discovery

OBJECTIVESWhen reconstructing fossil pelves, the articulation of the pelvic bones largely relies on subjective decisions by researchers. Different positionings at the pubic symphysis can affect the overall morphology of the pelvis and the subsequent…

Unraveling the Differentially Articulated Axes of the Century-Old Renin-Angiotensin-Aldosterone System: Potential Therapeutic Implications.

Article

Among numerous choices in cardiovascular therapies used for the management of hypertension and heart failure, drugs affecting the renin-angiotensin-aldosterone system (RAAS) hold substantial therapeutic roles. Therapies aimed at modifying the RAAS a…

Transverse Myelitis in a Healthy Patient With Benign Paroxysmal Positional Vertigo: A Case Report Highlighting Inpatient Rehabilitation and Functional Gains

Article

Transverse myelitis (TM), a poorly understood neurological disorder, can manifest in various clinical scenarios. We report a unique case where TM presented in a background of benign paroxysmal positional vertigo (BPPV). The patient, an otherwise hea…

Systemic Risks of Topical Anesthetics in Barrier-Compromised Dermatologic Patients

Article

Topical anesthetics are widely employed in dermatology for cosmetic interventions, laser therapies, and minor surgical procedures. Although generally safe, their systemic absorption is highly influenced by the integrity of the epidermal barrier. Inf…

A Review of the Recent Advances in the Pharmacological Management of Parkinson’s Disease

Article

AbstractParkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss ofdopaminergic neurons in the substantia nigra, leading to motor and nonmotor symptoms. Thepathophysiology of PD involves a complex interplay of g…

Compartment Syndrome of the Lower Limb in Adults and Children and Effective Surgical Intervention and Post-surgical Therapies: A Narrative Review

Article

Compartment syndrome (CS) can be defined as an acutely painful condition that occurs due to increased pressure within a compartment, resulting in reduced blood flow and oxygen to nerves and muscles within the limb. It is considered a surgical emerge…

Integrating nutrition and culinary medicine into preclinical medical training

Article

BACKGROUNDPoor nutrition is a leading cause of preventable death, but is inconsistently taught in medical education and inadequately discussed in medical care. To overcome this problem, we developed a hybrid nutrition team-based learning/culinary me…

Tackling the opioid epidemic: a virtual interprofessional workshop

Article

In response to the growing opioid epidemic in Fresno County, Central California, a virtual interprofessional workshop focusing on opioid misuse and overdose was developed and implemented for health professional providers and students in the local co…

Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress

Article

This study aimed to determine the effects of mitotherapy on learning and memory and hippocampal kynurenine (Kyn) pathway, mitochondria function, and dendritic arborization and spines density in aged rats subjected to chronic mild stress. Twenty-eigh…

Graft-Site Morbidity in Anterior Cruciate Ligament (ACL) Reconstruction: A Scoping Review of Assessment Techniques and Outcomes

Article

Abstract Graft-site morbidity is a critical yet often overlooked aspect of anterior cruciate ligament reconstruction (ACLR). While autografts such as bone-patellar tendon-bone (BPTB) and quadriceps tendon (QT) have been shown to provide effective me…

AbstractPsoriasis and atherosclerosis are chronic inflammatory conditions linkedby overlapping immunological pathways. Psoriasis, an autoimmuneskin disorder characterized by keratinocyte hyperproliferation andplaque formation, is associated with an …

AbstractBackgroundAtrial fibrillation (AF) is the most common treated cardiac arrhythmia in the United States, contributing substantially to morbidity, mortality, and healthcare costs. AF is associated with significant complications, including …

The impact of positive airway pressure (PAP) on severe Coronavirus Disease (COVID-19) among the patients with obstructive sleep apnea (OSA).

Article

BACKGROUNDObstructive sleep apnea (OSA) has been proposed as a risk factor for severe Coronavirus Disease (COVID-19). We hypothesized that treating OSA with positive airway pressure (PAP) decreases the risk of severe COVID-19. To answer this questio…