CHSU Discovery

A Review of Recent Advances in the Management of Alzheimer's Disease

Article

Alzheimer's disease (AD) is the most common neurodegenerative condition and a form of dementia encountered in medical practice. Despite many proposed and attempted treatments, this disease remains a major puzzle in the public health systems worldwid…

The impact of team-based learning on the critical thinking skills of pharmacy students

Article

INTRODUCTIONCritical thinking is an important ability for pharmacists, but few studies have found improvements in pharmacy student critical thinking skills as a consequence of their education. Team-based learning (TBL) is an active learning strategy…

OBJECTIVESWhen reconstructing fossil pelves, the articulation of the pelvic bones largely relies on subjective decisions by researchers. Different positionings at the pubic symphysis can affect the overall morphology of the pelvis and the subsequent…

Unraveling the Differentially Articulated Axes of the Century-Old Renin-Angiotensin-Aldosterone System: Potential Therapeutic Implications.

Article

Among numerous choices in cardiovascular therapies used for the management of hypertension and heart failure, drugs affecting the renin-angiotensin-aldosterone system (RAAS) hold substantial therapeutic roles. Therapies aimed at modifying the RAAS a…

Transverse Myelitis in a Healthy Patient With Benign Paroxysmal Positional Vertigo: A Case Report Highlighting Inpatient Rehabilitation and Functional Gains

Article

Transverse myelitis (TM), a poorly understood neurological disorder, can manifest in various clinical scenarios. We report a unique case where TM presented in a background of benign paroxysmal positional vertigo (BPPV). The patient, an otherwise hea…

Systemic Risks of Topical Anesthetics in Barrier-Compromised Dermatologic Patients

Article

Topical anesthetics are widely employed in dermatology for cosmetic interventions, laser therapies, and minor surgical procedures. Although generally safe, their systemic absorption is highly influenced by the integrity of the epidermal barrier. Inf…

A Review of the Recent Advances in the Pharmacological Management of Parkinson’s Disease

Article

AbstractParkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss ofdopaminergic neurons in the substantia nigra, leading to motor and nonmotor symptoms. Thepathophysiology of PD involves a complex interplay of g…

Compartment Syndrome of the Lower Limb in Adults and Children and Effective Surgical Intervention and Post-surgical Therapies: A Narrative Review

Article

Compartment syndrome (CS) can be defined as an acutely painful condition that occurs due to increased pressure within a compartment, resulting in reduced blood flow and oxygen to nerves and muscles within the limb. It is considered a surgical emerge…

Integrating nutrition and culinary medicine into preclinical medical training

Article

BACKGROUNDPoor nutrition is a leading cause of preventable death, but is inconsistently taught in medical education and inadequately discussed in medical care. To overcome this problem, we developed a hybrid nutrition team-based learning/culinary me…

Tackling the opioid epidemic: a virtual interprofessional workshop

Article

In response to the growing opioid epidemic in Fresno County, Central California, a virtual interprofessional workshop focusing on opioid misuse and overdose was developed and implemented for health professional providers and students in the local co…

Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress

Article

This study aimed to determine the effects of mitotherapy on learning and memory and hippocampal kynurenine (Kyn) pathway, mitochondria function, and dendritic arborization and spines density in aged rats subjected to chronic mild stress. Twenty-eigh…

Dabrafenib and steroids for the treatment of Erdheim-Chester disease with extensive CNS involvement: a case report

Article

Erdheim-Chester disease (ECD) is an exceedingly rare non-Langerhans cell CD68+ CD1a- S100- histiocytic multi-organ disease. Diagnosis of ECD is often delayed due to non-specific radiographic findings and heterogeneous lesional tissue. Increasingly, …

Comparative Analysis of LLMs in Dry Eye Syndrome Healthcare Information

Article

Background/Objective: Dry eye syndrome affects 16 million Americans with USD 52 billion in annual healthcare costs. With large language models (LLMs) increasingly used for healthcare information, understanding their performance in delivering equitab…

Scheuermann Kyphosis: Current Concepts and Management

Article

PURPOSE OF REVIEWScheuermann's kyphosis (SK) is a developmental deformity of the spine that affects up to 8% of children in the US. Although, the natural progression of SK is noted to be gradual over years, severe deformity can be associated with si…

Top 100 cited articles in osteopathic medical education: A bibliometric analysis

Article

Context Bibliometric analysis is a method for analyzing the existing literature of a specific research area. Because it provides information about current research trends, the analysis can highlight attributes of frequently cited articles and ident…

Renin angiotensin aldosterone system in pulmonary fibrosis: Pathogenesis to therapeutic possibilities.

Review Article

Pulmonary fibrosis is a devastating lung disease with multifactorial etiology characterized by alveolar injury, fibroblast proliferation and excessive deposition of extracellular matrix proteins, which progressively results in respiratory failure an…

Optimal Glucose Reduction in Diabetic Emergencies (OG-RIDE).

Article

BACKGROUNDTo minimize the risk of cerebral edema in the management of hyperglycemic emergencies, guidelines recommend gradually decreasing serum glucose levels, but there is limited literature validating these reduction goals or evaluating outcomes …

Diffuse Bi-hemispheric Cortical Infarction Secondary to Cerebral Air Embolism After Elective Esophagogastroduodenoscopy: A Case Report and Review of Literature

Article

Cerebral air embolism (CAE) is a rare entity and is more often secondary to iatrogenic causes. We present a rare case of CAE post esophagogastroduodenoscopy (EGD) with a shower of emboli resulting in diffuse cortical infarction. An 80-year-old man w…

Patients With Systemic Reaction to Their Hernia Mesh: An Introduction to Mesh Implant Illness

Article

In our practice, we have noticed an increased number of patients requiring mesh removal due to a systemic reaction to their implant. We present our experience in diagnosing and treating a subpopulation of patients who require mesh removal due to a p…