CHSU Discovery

Wnt Pathway-Targeted Therapy in Gastrointestinal Cancers: Integrating Benchside Insights with Bedside Applications

Article

The Wnt signaling pathway is critical in the onset and progression of gastrointestinal (GI) cancers. Anomalies in this pathway, often stemming from mutations in critical components such as adenomatous polyposis coli (APC) or β-catenin, lead to uncon…

Single Accreditation and The Match: How Does the Change Affect Osteopathic Graduates?

Article

This article was migrated. The article was marked as recommended. There is a predicted serious shortage of physicians in the US. To overcome this problem, medical schools have expanded at the behest of the US Government by number and by overall grad…

Mesenchymal stem cell-derived exosomes improve neurogenesis and cognitive function of mice with methamphetamine addiction: A novel treatment approach

Article

BACKGROUNDMethamphetamine (METH) is a psychostimulant substance with highly addictive and neurotoxic effects, but no ideal treatment option exists to improve METH-induced neurocognitive deficits. Recently, mesenchymal stem cells (MSCs)-derived exoso…

A Boy with an Itch: A Case Report of Genital Nodular Scabies

Article

Scabies is an enormous global public health problem and one of the World Health Organization's 20 most neglected tropical diseases. Scabies affects all groups with children and elderly, particularly in resource scarce countries, among the most vulne…

Long-term aspirin use in patients hospitalized with ischemic colitis

Article

BackgroundIschemic colitis is a form of mesenteric ischemia that often presents in patients with vascular disease. Long-term aspirin use has been shown to improve the outcomes in patients with cardiovascular or cerebrovascular disease. However, the …

Tranexamic Acid for the Treatment of Acute Gastrointestinal Bleeding in a Jehovah's Witness Patient on Apixaban and Dual Antiplatelet Therapy: A Case Report

Article

Life-threatening bleeding can be challenging to manage, especially in patients who reject allogeneic transfusions for religious or personal reasons. Tranexamic acid (TXA) has been successfully used to treat acute bleeding in multiple settings with v…

Local tumor destruction and liver resection increase overall survival in intermediate/advanced hepatocellular carcinoma patients: evidence from a population-based study

Article

BackgroundLiver resection (LR) and local tumor destruction (LTD) are effective treatments, but not commonly recommended for patients with intermediate/advanced hepatocellular carcinoma (HCC). This study aimed to explore whether LR/LTD could improve …

Training Medical Students in Diet Assessment and Brief Counseling.

Article

Poor dietary choices are a leading cause of chronic disease, but nutrition is rarely discussed in clinical practice. Nutrition is taught in less than a third of medical schools and physicians in practice empirically report low levels of comfort and …

A Comprehensive Review of Novel FDA-Approved Psychiatric Medications (2018-2022)

Article

Mental health disorders are among the top leading causes of disease burden worldwide and many patients have high levels of treatment resistance. Even though medications offer improvement to some patients, antidepressants are only effective in about …

A Worsening Cough: An Unusual Presentation of Malignant Mesothelioma

Article

Localized malignant pleural mesothelioma (LMPM) is a rare cancer with poor survival rates. Often affecting males with asbestos exposure, we report a case of a 56-year-old female with no history of occupational exposure presenting with a worsening co…

Progress and perspectives of carbon nanomaterials based electrochemical modifiers for the detection of environmental contaminants

Article

To safeguard human health, environmental pollutants must be thoroughly screened to determine their acceptable limit. Several methods have been developed to identify environmental contaminants. Nevertheless, these methods have several disadvantages. …

Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin

Article

Lysine-proline-valine (KPV) is a C-terminal peptide fragment of α-melanocyte stimulating hormone with potent anti-inflammatory properties. Present study investigates various transdermal enhancement strategies such as iontophoresis (ITP), microneedle…

Tracheomalacia in Adults: An Uncommon Cause of Dyspnea

Article

Tracheomalacia (TM), the most common congenital tracheal defect, is due to compromised cartilage integrity, manifesting in the narrowing of expiratory airways and various respiratory symptoms. While TM is common in infants and toddlers, it is rarely…

The identification and genetic characteristics of Quang Binh virus from field-captured Culex tritaeniorhynchus (Diptera: Culicidae) from Guizhou Province, China

Article

BACKGROUNDMosquitoes carry a variety of viruses that can cause disease in humans, animals and livestock. Surveys for viruses carried by wild mosquitoes can significantly contribute to surveillance efforts and early detection systems. In addition to …

P2Y purinergic signaling in prostate cancer: Emerging insights into pathophysiology and therapy.

Article

Despite recent advances in the treatment landscape for prostate cancer, many challenges still remain. A more profound understanding of prostate cancer pathogenesis and the underlying mechanisms is critical to developing novel therapeutics strategies…

AMPK Signaling Pathway as a Potential Therapeutic Target for Parkinson's Disease

Article

Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the loss of dopaminergic neurons. Genetic factors, inflammatory responses, oxidative stress, metabolic disorders, cytotoxic factors, and mitochondrial dysfunction…

Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone

Article

BACKGROUNDLicorice is an herb extensively used for both culinary and medicinal purposes. Various constituents of licorice have been shown to exhibit anti-tumorigenic effect in diverse cancer types. However, majority of these studies focus on the asp…

Airway Management in Patients With Vocal Cord Paralysis: A Review of Intubation Techniques, Intraoperative Challenges, and Outcomes.

Article

Vocal cord paralysis (VCP) presents with unique challenges when managing airways, particularly during endotracheal intubation. This literature review explores the effects of unilateral and bilateral VCP on intubation technique, first-pass success, e…

Orbital Osteomyelitis and Periorbital Abscess Due to Coccidioidomycosis Following Trauma

Article

Ocular involvement due to Coccidioides sp.is extremely rare, and most patients with disseminated coccidioidomycosis present as extrapulmonary or disseminated disease that involves the skin, bone joints, and central nervous system. Here, we describe …