CHSU Discovery

Predictors of Major Bleeding Among Working-Age Adults with Atrial Fibrillation: Evaluating the Effects of Potential Drug-drug Interactions and Switching from Warfarin to Non-vitamin K Oral Anticoagulants

Article

PURPOSEThis study aims to evaluate the associations between switching from warfarin to non-vitamin K oral anticoagulants (NOACs), exposure to potential drug-drug interactions (DDIs), and major bleeding events in working-age adults with atrial fibril…

ABSTRACTAcute kidney injury (AKI) is commonly caused by medications including, but not limited to,aminoglycosides, cephalosporins, penicillins, trimethoprim-sulfamethoxazole, and amphotericin.Among pediatric patients, clindamycin has been widely use…

Utility of nicardipine in the management of hypertensive crises in adults with reduced ejection fractions

Article

BACKGROUNDNicardipine is commonly used in the management of hypertensive crises, except those involving cardiac contractility defects despite its ability to reduce afterload and pulmonary congestion. Consequently, there is limited literature evaluat…

Structured Interviews Reveal That Reference and Liaison Librarians—as Engaged, Proactive Partners—are Vital to the Academic Enterprise

Review Article

A Review of: Johnson, A.M. (2020). Reference and liaison librarians: Endangered species or “vital partners?” Views of academic library administrators. Journal of Library Administration, 60(7), 784-799. https://doi.org/10.1080/01930826.2020.178697…

When Fantasy Feels Too Real: The Psychological Toll of Deep Media Attachment.

Article

Parasocial relationships (PSRs) are emotional relationships developed with a media figure. These relationships may take the form of friendship, romantic attachments, or the embodiment of the persona. This case study highlights the psychological impa…

Integrating PICO principles into generative artificial intelligence prompt engineering to enhance information retrieval for medical librarians

Article

Prompt engineering, an emergent discipline at the intersection of Generative Artificial Intelligence (GAI), library science, and user experience design, presents an opportunity to enhance the quality and precision of information retrieval. An innova…

The Irony of Iron Pill Gastritis: A Case of Delayed Recognition and Persistent Injury in an Elderly Patient

Article

Iron pill gastritis is an underrecognized complication of oral solid iron supplementation, particularly in elderly patients. We present the case of an 83-year-old male with a history of hypertension, hyperlipidemia, type II diabetes, and chronic gas…

Non-pharmacological therapeutic paradigms in stress-induced depression: from novel therapeutic perspective with focus on cell-based strategies

Article

Major depressive disorder (MDD) is considered a psychiatric disorder and have a relationship with stressful events. Although the common therapeutic approaches against MDD are diverse, a large number of patients do not present an adequate response to…

Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain.

Article

Age-related neurodegenerative diseases and vascular dementia are major challenges to the modern health care system. Most neurodegenerative diseases are associated with impaired spatial working memory and anxiety-like behavior. Thus, it is important …

A Comprehensive Reflective Journal-Writing Framework for Pharmacy Students to Increase Self-Awareness and Develop Actionable Goals

Article

Objective. To develop and evaluate the effectiveness of a structured model for reflective journal writing (RJW) and a grading rubric as part of a student portfolio designed to help Doctor of Pharmacy (PharmD) students create actionable goals. Method…

Incorporating Augmented Reality Into Anatomy Education in a Contemporary Medical School Curriculum

Article

Anatomy education in the medical school curriculum has encountered considerable challenges during the last decade. The exponential growth of medical science has necessitated a review of the classical ways to teach anatomy to shorten the time student…

Obesity and Aging

Article

The obesity epidemic in aging populations poses significant public health concerns for greater morbidity and mortality risk. Age-related increased adiposity is multifactorial and often associated with reduced lean body mass. The criteria used to def…

Effect of prenatal exposure to stress and extremely low-frequency electromagnetic field on hippocampal and serum BDNF levels in male adult rat offspring

Article

ObjectivesPrenatal stress (PS) can adversely affect cognitive and psychological functions in the offspring. This study aimed to determine the effect of PS and extremely low-frequency electromagnetic field (ELF-EMF) on spatial memory, serum corticost…

Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats.

Article

BACKGROUND AND PURPOSEThe therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat controversial. Recent results from our laboratory have demonstrated the potential benefits of human umbilical cord bloo…

Acute Acalculous Cholecystitis in a Patient With Pancolitis: A Case Report

Article

Salmonella is an infectious bacterial organism found in many food products. In this case, there is an investigation into salmonella infection leading to acute acalculous cholecystitis (AAC). Pancolitis, although mostly caused by ulcerative colitis, …

Services and staffing practices in academic health sciences libraries serving college of osteopathic medicine programs: a mixed methods study

Article

OBJECTIVEThis study describes and assesses services, staffing practices, and trends in academic health sciences libraries that serve accredited college of osteopathic medicine (COM) programs in the United States.METHODSThe study was conducted in thr…

Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers

Article

BACKGROUNDQuercetin (QCT), a naturally occurring flavonoid has a wide array of pharmacological properties such as anticancer, antioxidant and anti-inflammatory activities. QCT has low solubility in water and poor bioavailability, which limited its u…

Intranasal AdipoRon mitigates motor and cognitive deficits in hemiparkinsonian rats through neuroprotective mechanisms against oxidative stress and synaptic dysfunction

Article

While motor symptoms are the most well-known manifestation of Parkinson's disease (PD), patients may also suffer from non-motor signs like cognitive impairments. The adiponectin receptor agonist AdipoRon (Adipo) has shown neuroprotective effects in …

Benefits and Risks of Medications Used in the Management of Hypotension: A Review

Article

This comprehensive literature review addresses the scarcity and limited study of hypotension treatments compared to abundant antihypertensive drugs. Hypotension, categorized as absolute, relative, or orthostatic, has diverse causes. This review expl…

A Retrospective Study of Outcomes in a Rural Pediatric Population Treated for Venous Insufficiency

Article

BACKGROUNDEndovascular radiofrequency ablation (RFA) and Endovascular Laser Ablation (EVLA) are minimally invasive methods to safely treat symptomatic varicose veins in pediatric patients. This research aimed to review the management of pediatric pa…