CHSU Discovery

A System-Based Review on Effects of Glucagon-Like Peptide-1 Receptor Agonists: Benefits vs Risks

Article

Glucagon-like peptide 1 (GLP-1), an incretin hormone primarily secreted by L-cells in the gut, prompts insulin release, thus reducing blood sugar levels and causing weight loss by inducing feelings of fullness while curbing appetite. GLP-1 receptor …

An Industrial Engineering Approach to Cost Containment of Pharmacy Education

Article

A 2-semester project explored employing teams of fourth-year industrial engineering students to optimize some of our academic management processes. Results included significant cost savings and increases in efficiency, effectiveness, and student and…

A Prospective Observational Study Assessing the Impacts of Health Literacy and Psychosocial Determinants of Health on 30-day Readmission Risk.

Article

Our objective was to assess the utility of an assessment battery capturing health literacy (HL) and biopsychosocial determinants of health in predicting 30-day readmission in comparison to a currently well-adopted readmission risk calculator. We als…

Antioxidant and anticancer activities of green synthesized silver nanoparticles using aqueous extract of tubers of Pueraria tuberosa

Article

In the present study, we have synthesized silver nanoparticles (AgNPs) using Pueraria tuberosa aqueous extract (PTAE) in a straightforward manner without involvement of toxic chemicals. Various reaction parameters (reaction time, AgNO3 concentration…

Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex

Article

Along with altering brain responses to stress, aging may also impair recovery from depression symptoms. In the present study, we investigated depressive-like behaviors in young and aged rats and assayed the levels of microRNA-101 (miR-101), Rac1/Rho…

Advancing Breast Cancer Research Through Collaborative Computing: Harnessing Google Colab for Innovation

Article

This investigation explores the potential efficacy of machine learning algorithms (MLAs), particularly convolutional neural networks (CNNs), in distinguishing between benign and malignant breast cancer tissue through the analysis of 1000 breast canc…

A Case of Complex Regional Pain Syndrome With Hypermobile Ehlers-Danlos Syndrome and Mast Cell Activation Syndrome: The Role of Unconventional Therapies

Article

Complex regional pain syndrome (CRPS) type 2 is a chronic pain condition that develops after a nerve injury and is characterized by severe pain, allodynia, and functional impairments. Ehlers-Danlos syndrome hypermobility type (hEDS) and mast cell ac…

All pain, no gain: When epididymitis drops the ball

Article

Testicular infarction due to acute epididymitis is a rare but serious complication caused by inflammation that impairs blood flow to the testis. Epididymitis, frequently associated with bacterial infections, usually presents with scrotal pain and sw…

AdipoRon Mitigates Anxiety and Depression Symptoms in Chronic Sleep-Restricted Mice via Modulation of Neuroinflammatory Responses

Article

The contemporary lifestyle has resulted in an epidemic of chronic sleep restriction (SR), which has emerged as a substantial contributor to mood disorders, particularly anxiety and depression. This study examined the effectiveness of AdipoRon (Adipo…

AdipoRon improves mitochondrial homeostasis and protects dopaminergic neurons through activation of the AMPK signaling pathway in the 6-OHDA-lesioned rats

Article

The progressive decline of dopaminergic neurons in Parkinson's disease (PD) has been linked to an imbalance in energy and the failure of mitochondrial function. AMP-activated protein kinase (AMPK), the major intracellular energy sensor, regulates en…

A 44-Year-Old Male With Cerebral Venous Sinus Thrombosis

Article

Cerebral venous sinus thrombosis (CVST) is a rare condition that can result in severe neurological complications when left untreated. Disease pathology results from thrombus development within the superficial cortical veins or the dural sinuses. Thr…

Acute Management of Hypertriglyceridemia With a Disease-Specific Intravenous Insulin Infusion Order Set

Article

BACKGROUNDHypertriglyceridemia-associated acute pancreatitis is a disease lacking a standardized management approach.OBJECTIVEThe main objective of this study was to evaluate the safety and efficacy of a continuous intravenous insulin infusion order…

A Review of Recent Advances in the Management of Alzheimer's Disease

Article

Alzheimer's disease (AD) is the most common neurodegenerative condition and a form of dementia encountered in medical practice. Despite many proposed and attempted treatments, this disease remains a major puzzle in the public health systems worldwid…

A Review of the Recent Advances in the Pharmacological Management of Parkinson’s Disease

Article

AbstractParkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss ofdopaminergic neurons in the substantia nigra, leading to motor and nonmotor symptoms. Thepathophysiology of PD involves a complex interplay of g…

A Boy with an Itch: A Case Report of Genital Nodular Scabies

Article

Scabies is an enormous global public health problem and one of the World Health Organization's 20 most neglected tropical diseases. Scabies affects all groups with children and elderly, particularly in resource scarce countries, among the most vulne…

A Comprehensive Review of Novel FDA-Approved Psychiatric Medications (2018-2022)

Article

Mental health disorders are among the top leading causes of disease burden worldwide and many patients have high levels of treatment resistance. Even though medications offer improvement to some patients, antidepressants are only effective in about …

A Worsening Cough: An Unusual Presentation of Malignant Mesothelioma

Article

Localized malignant pleural mesothelioma (LMPM) is a rare cancer with poor survival rates. Often affecting males with asbestos exposure, we report a case of a 56-year-old female with no history of occupational exposure presenting with a worsening co…

AMPK Signaling Pathway as a Potential Therapeutic Target for Parkinson's Disease

Article

Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the loss of dopaminergic neurons. Genetic factors, inflammatory responses, oxidative stress, metabolic disorders, cytotoxic factors, and mitochondrial dysfunction…