CHSU Discovery

When the social distancing guidelines, as a result of the COVID-19 pandemic, caused universities to close campuses, there was a rapid shift in the course delivery methods of human gross anatomy laboratory sessions. Courses were delivered online, and…

Intranasal AdipoRon Mitigated Anxiety and Depression-Like Behaviors in 6-OHDA-Induced Parkinson 's Disease Rat Model: Going Beyond Motor Symptoms

Article

Depression and anxiety are prevalent neuropsychiatric conditions among patients with Parkinson's disease (PD), which may manifest prior to motor symptoms. As levodopa, a prominent treatment for PD motor symptoms, provides few benefits for mood-relat…

The intense inflammatory response triggered in the brain after focal cerebral ischemia is detrimental. Recently, we showed that the suppression of toll-like receptors (TLRs) 2 and 4 attenuates infarct size and reduces the expression of pro-inflammat…

To better understand the homeostatic mechanisms governing melanocytes, we performed deep phenotyping of clonal expansions of single melanocytes from human skin. In total, we interrogated the mutational landscapes, gene expression profiles, and morph…

Acute Large Bowel Obstruction Post Umbilical Hernia Repair Surgery: A Case Report

Article

While large bowel obstruction (LBO) is a less common cause of bowel obstruction, it has a broad range of differentials. Its most common etiology in the United States is colorectal adenocarcinoma. Patients usually present with diffuse abdominal pain,…

Comparison of rerupture rates after operative and nonoperative management of Achilles tendon rupture in older populations: Systematic review and meta-analysis

Article

BackgroundThis systematic review and meta-analysis investigated the treatment for Achilles tendon rupture (ATR) associated with the lowest risk of rerupture in older patients.MethodsFive databases were searched through September 2022 for studies pub…

Current Impact and Application of Abuse-Deterrent Opioid Formulations in Clinical Practice

Article

BACKGROUNDAbuse-deterrent formulations (ADFs) represent one novel strategy for curbing the potential of opioid abuse.OBJECTIVEWe aim to compare and contrast the characteristics and applications of current abuse-deterrent opioid products in clinical …

A fraction of Pueraria tuberosa extract, rich in antioxidant compounds, alleviates ovariectomized-induced osteoporosis in rats and inhibits growth of breast and ovarian cancer cells.

Article

Pueraria tuberosa (Roxb. ex Willd.) DC., known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy of an ethyl acetate fraction from the tuber extract …

Graft-Site Morbidity in Anterior Cruciate Ligament (ACL) Reconstruction: A Scoping Review of Assessment Techniques and Outcomes

Article

Abstract Graft-site morbidity is a critical yet often overlooked aspect of anterior cruciate ligament reconstruction (ACLR). While autografts such as bone-patellar tendon-bone (BPTB) and quadriceps tendon (QT) have been shown to provide effective me…

AbstractPsoriasis and atherosclerosis are chronic inflammatory conditions linkedby overlapping immunological pathways. Psoriasis, an autoimmuneskin disorder characterized by keratinocyte hyperproliferation andplaque formation, is associated with an …