CHSU Discovery

All pain, no gain: When epididymitis drops the ball

Article

Testicular infarction due to acute epididymitis is a rare but serious complication caused by inflammation that impairs blood flow to the testis. Epididymitis, frequently associated with bacterial infections, usually presents with scrotal pain and sw…

Current Impact and Application of Abuse-Deterrent Opioid Formulations in Clinical Practice

Article

BACKGROUNDAbuse-deterrent formulations (ADFs) represent one novel strategy for curbing the potential of opioid abuse.OBJECTIVEWe aim to compare and contrast the characteristics and applications of current abuse-deterrent opioid products in clinical …

A fraction of Pueraria tuberosa extract, rich in antioxidant compounds, alleviates ovariectomized-induced osteoporosis in rats and inhibits growth of breast and ovarian cancer cells.

Article

Pueraria tuberosa (Roxb. ex Willd.) DC., known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy of an ethyl acetate fractio…

The identification and genetic characteristics of Quang Binh virus from field-captured Culex tritaeniorhynchus (Diptera: Culicidae) from Guizhou Province, China

Article

BACKGROUNDMosquitoes carry a variety of viruses that can cause disease in humans, animals and livestock. Surveys for viruses carried by wild mosquitoes can significantly contribute to surveillance efforts and early detection systems. In addition to …

P2Y purinergic signaling in prostate cancer: Emerging insights into pathophysiology and therapy.

Article

Despite recent advances in the treatment landscape for prostate cancer, many challenges still remain. A more profound understanding of prostate cancer pathogenesis and the underlying mechanisms is critical to developing novel therapeutics strategies…

Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report

Article

We present the first documented case of metastatic melanoma to the orbit with dedifferentiation. A patient with a history of melanoma of the lip and other poorly differentiated carcinomas presented with both a sub-brow and an intraorbital mass. Radi…

Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension

Article

Pulmonary hypertension (PH) is a devastating disease and its successful treatment remains to be accomplished despite recent advances in pharmacotherapy. It has been proposed that PH be considered as a systemic disease, rather than primarily a diseas…

Chatbots and Diabetes: Is There Gender Bias?

Article

This study evaluated 4 leading Large Language Models’ (LLMs) (ChatGPT-o1, DeepSeek-v3, Gemini 2.0 Flash, and Claude 3.7 Sonnet) responses to a question about Diabetic Retinopathy. Methods: The following questions were posed to the 4 LLMS: “I am a 52…

Blending team-based learning and game-based learning in pharmacy education.

Article

BACKGROUND AND PURPOSETeam-based learning (TBL) and game-based learning (GBL) are evidence-based active learning pedagogies. This study reports a learning experience that harnesses TBL and GBL benefits by blending both pedagogies (referred herein as…

Drug-induced pancreatitis (DIP), while not a major cause of acute pancreatitis, remains a debilitating diagnosis resulting in significant patient morbidity and mortality. The diagnosis includes first diagnosing acute pancreatitis, second ruling out …

The effects of age, genotype and diet on hippocampal subfield iron dysregulation and Alzheimer's disease biomarkers in an ApoE mouse model

Article

Current theories regarding accumulation of Alzheimer's disease-related deposits of abnormal intra- and extracellular proteins include reactions to inflammation and mitochondrial dysfunction. In this study, we explored whether age, genotype and infla…

Tissue Augmentation Techniques in the Management of Ligamentous Knee Injuries

Article

Despite early reports of high failure rates in knee ligament repair techniques resulting in favor of reconstruction, newer advances in surgical technology have shifted the attention back to repair with the addition of various tissue augmentation tec…

Safety and Effectiveness of a Standardized Intravenous Insulin Infusion Order Set for Managing Uncontrolled Hyperglycemia Outside the Intensive Care Unit

Article

BACKGROUNDFew studies have evaluated the administration of intravenous (IV) insulin infusions for uncontrolled hyperglycemia in non-intensive care unit (ICU) patients, and there is inadequate data to guide how to appropriately administer IV insulin …

Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c)

Article

The Mycobacterium tuberculosis (Mtb) serine protease Hip1 (hydrolase important for pathogenesis; Rv2224c) promotes tuberculosis (TB) pathogenesis by impairing host immune responses through proteolysis of a protein substrate, Mtb GroEL2. The cell sur…

Transforming Prescription Opioid Practices in Primary Care With Change Theory

Article

The opioid epidemic continues to be an ongoing public health crisis. Many primary health care providers aptly serve as the gatekeeper to opioid prescriptions. The opioid epidemic has challenged the primary care profession whilst many of these provid…

Blast-Related Mild Traumatic Brain Injury: Case Report Highlighting the Long-Term Neurocognitive Sequelae Following Blast Exposure in Veterans.

Article

Traumatic brain injury (TBI) remains a significant public health concern, particularly among military service members exposed to blast-related trauma. While mild TBIs often resolve within weeks, a subset of patients may experience lifelong, persiste…

A 44-Year-Old Male With Cerebral Venous Sinus Thrombosis

Article

Cerebral venous sinus thrombosis (CVST) is a rare condition that can result in severe neurological complications when left untreated. Disease pathology results from thrombus development within the superficial cortical veins or the dural sinuses. Thr…

BACKGROUNDDistal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types: Supracondylar (SC), lateral condyle (LC), and medial epicondyle (ME) fractures.AIMTo evaluate the epi…

AdipoRon improves mitochondrial homeostasis and protects dopaminergic neurons through activation of the AMPK signaling pathway in the 6-OHDA-lesioned rats

Article

The progressive decline of dopaminergic neurons in Parkinson's disease (PD) has been linked to an imbalance in energy and the failure of mitochondrial function. AMP-activated protein kinase (AMPK), the major intracellular energy sensor, regulates en…

Vascular Endothelial Cell-Specific Connective Tissue Growth Factor (CTGF) Is Necessary for Development of Chronic Hypoxia-Induced Pulmonary Hypertension

Article

Chronic hypoxia frequently complicates the care of patients with interstitial lung disease, contributing to the development of pulmonary hypertension (PH), and premature death. Connective tissue growth factor (CTGF), a matricellular protein of the C…