CHSU Discovery

Elevation through reflection: closing the circle to improve librarianship

Article

Reflective practice is a strategy promoted as a way to improve professional performance and to develop expertise. Intentional reflection on work situations can lead to improved understanding of a specific situation, identify strategies for similar s…

SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets.

Article

BACKGROUNDThe ongoing COVID-19 outbreak has caused devastating mortality and posed a significant threat to public health worldwide. Despite the severity of this illness and 2.3 million worldwide deaths, the disease mechanism is mostly unknown. Previ…

Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma.

Article

INTRODUCTIONRecent studies have suggested that dysregulated Hippo pathway signaling may contribute to glioblastoma proliferation and invasive characteristics. The downstream effector of the pathway, the Yes-associated protein (YAP) oncoprotein, has …

Current hyperkalemia interventions co-administered with a dextrose 10% solution significantly lower hypoglycemic rates (CHICA-D10)

Article

BACKGROUNDCurrent protocols which include the administration of a single dextrose dose concomitantly with insulin are inadequate as hypoglycemia commonly occurs 60 min after insulin administration and may persist for up to two hours post-insulin adm…

Advancing Breast Cancer Research Through Collaborative Computing: Harnessing Google Colab for Innovation

Article

This investigation explores the potential efficacy of machine learning algorithms (MLAs), particularly convolutional neural networks (CNNs), in distinguishing between benign and malignant breast cancer tissue through the analysis of 1000 breast canc…

A Case of Complex Regional Pain Syndrome With Hypermobile Ehlers-Danlos Syndrome and Mast Cell Activation Syndrome: The Role of Unconventional Therapies

Article

Complex regional pain syndrome (CRPS) type 2 is a chronic pain condition that develops after a nerve injury and is characterized by severe pain, allodynia, and functional impairments. Ehlers-Danlos syndrome hypermobility type (hEDS) and mast cell ac…

All pain, no gain: When epididymitis drops the ball

Article

Testicular infarction due to acute epididymitis is a rare but serious complication caused by inflammation that impairs blood flow to the testis. Epididymitis, frequently associated with bacterial infections, usually presents with scrotal pain and sw…

mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics

Article

The Hippo and mTOR signaling cascades are major regulators of cell growth and division. Aberrant regulation of these pathways has been demonstrated to contribute to gliomagenesis and result in enhanced glioblastoma proliferation and invasive charact…

Intranasal AdipoRon improves motor function in a rat model of Parkinson's disease by promoting neurogenesis in the nigrostriatal pathway.

Article

Parkinson's disease (PD) is a neurodegenerative disorder characterized by drastically reduced synaptic plasticity and neurogenesis, possibly due to abnormal α-synuclein deposition. Boosting endogenous neurogenesis is a potential strategy for halting…

A 44-Year-Old Male With Cerebral Venous Sinus Thrombosis

Article

Cerebral venous sinus thrombosis (CVST) is a rare condition that can result in severe neurological complications when left untreated. Disease pathology results from thrombus development within the superficial cortical veins or the dural sinuses. Thr…

BACKGROUNDDistal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types: Supracondylar (SC), lateral condyle (LC), and medial epicondyle (ME) fractures.AIMTo evaluate the epi…

AdipoRon improves mitochondrial homeostasis and protects dopaminergic neurons through activation of the AMPK signaling pathway in the 6-OHDA-lesioned rats

Article

The progressive decline of dopaminergic neurons in Parkinson's disease (PD) has been linked to an imbalance in energy and the failure of mitochondrial function. AMP-activated protein kinase (AMPK), the major intracellular energy sensor, regulates en…

Vascular Endothelial Cell-Specific Connective Tissue Growth Factor (CTGF) Is Necessary for Development of Chronic Hypoxia-Induced Pulmonary Hypertension

Article

Chronic hypoxia frequently complicates the care of patients with interstitial lung disease, contributing to the development of pulmonary hypertension (PH), and premature death. Connective tissue growth factor (CTGF), a matricellular protein of the C…

When Fantasy Feels Too Real: The Psychological Toll of Deep Media Attachment.

Article

Parasocial relationships (PSRs) are emotional relationships developed with a media figure. These relationships may take the form of friendship, romantic attachments, or the embodiment of the persona. This case study highlights the psychological impa…

Correction: A Comprehensive Review of Novel FDA-Approved Psychiatric Medications (2018-2022)

Article

[This corrects the article DOI: 10.7759/cureus.56561.].

INTRODUCTIONCrowdsourcing is a method of data collection with possible benefits in assessing perceptions of mental illness in a large US population.METHODSThe objective was to describe perceptions and trends of stigma surrounding mental illness in t…

A comprehensive review of clinical experiences and extracurricular activities for US premedical students applying to osteopathic medical schools

Article

CONTEXTThe healthcare industry faces a critical shortage of qualified physicians. To address this growing concern, medical schools nationwide are increasing their efforts to recruit and train premedical students to fill this gap. Those efforts inclu…

Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension

Article

Pulmonary hypertension (PH) complicates the care of patients with chronic lung disease, such as idiopathic pulmonary fibrosis (IPF), resulting in a significant increase in morbidity and mortality. Disease pathogenesis is orchestrated by unidentified…

Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer

Article

Genistein (GEN), a natural isoflavone possesses a wide range of pharmacological properties and nutraceutical applications. GEN has been studied for its anticancer activity against different types of cancers, but its use in clinical practice is limit…