CHSU Discovery

Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer

Article

Genistein (GEN), a natural isoflavone possesses a wide range of pharmacological properties and nutraceutical applications. GEN has been studied for its anticancer activity against different types of cancers, but its use in clinical practice is limit…

Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension

Article

Pulmonary hypertension (PH) complicates the care of patients with chronic lung disease, such as idiopathic pulmonary fibrosis (IPF), resulting in a significant increase in morbidity and mortality. Disease pathogenesis is orchestrated by unidentified…

Exploring the Therapeutic Potential of Ketamine and Psilocybin in Comparison to Current Treatment Regimens for Treatment-Resistant Depression, Mood Disorders, and Post-traumatic Stress Disorder in the Pediatric Population: A Narrative Review.

Article

The stresses of the Coronavirus Disease of 2019 (COVID-19) pandemic highlighted the burden of psychiatric disorders within the pediatric population, revealing a pre-existing need for rapid-onset therapies that have since driven efforts to expand eff…

Effect of prenatal exposure to stress and extremely low-frequency electromagnetic field on hippocampal and serum BDNF levels in male adult rat offspring

Article

ObjectivesPrenatal stress (PS) can adversely affect cognitive and psychological functions in the offspring. This study aimed to determine the effect of PS and extremely low-frequency electromagnetic field (ELF-EMF) on spatial memory, serum corticost…

Incorporating ACPE Standards in a Holistic Approach to School Operations and Accreditation

Article

Auburn University Harrison School of Pharmacy (AUHSOP) implemented a comprehensive, holistic process of continuous quality improvement (CQI) for its program using the Accreditation Council for Pharmacy Education's (ACPE) Accreditation Standards as t…

Critical Appraisal of Biomedical Literature With a Succinct Journal Club Template: The ROOTs Format

Article

Journal clubs are a valuable tool to assist pharmacists in the evaluation of biomedical literature and to promote adoption of evidence-based practices. The concise ROOTs (relevance, observe validity, obtain clinically significant results, and transl…

Understanding Public Perception of Over-the-Counter Hearing Aids: A Sentiment and Thematic Analysis of Consumer Reviews

Article

ObjectiveTo analyze public perceptions of over-the-counter (OTC) hearing aids through sentiment and thematic analysis of online consumer reviews and their changes over time.Study DesignSentiment and thematic analysis.SettingOnline reviews from third…

Recent Advances in the Management of Dyslipidemia: A Systematic Review

Article

Dyslipidemia refers to abnormal levels of lipids in the bloodstream, typically exhibiting an increased pattern. Total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides (TGs) are…

Although peer evaluations are essential to team-based learning, they can be problematic. Team activity debriefings (TAD) are advantageous because they focus on the team's problem-solving strategies and teamwork skills. Students (N = 100) who used bo…

Relevance of epithelial-to-pericyte transition in cancer

Article

The relevance of epithelial-to-mesenchymal transition (EMT) in cancer is still under debate. Recently, we reported that EMT bestows key pericyte properties on cancer cells and may thus represent epithelial-to-pericyte transition (EPT). Carcinoma cel…

INTRODUCTIONCrowdsourcing is a method of data collection with possible benefits in assessing perceptions of mental illness in a large US population.METHODSThe objective was to describe perceptions and trends of stigma surrounding mental illness in t…

Correction: A Comprehensive Review of Novel FDA-Approved Psychiatric Medications (2018-2022)

Article

[This corrects the article DOI: 10.7759/cureus.56561.].

A comprehensive review of clinical experiences and extracurricular activities for US premedical students applying to osteopathic medical schools

Article

CONTEXTThe healthcare industry faces a critical shortage of qualified physicians. To address this growing concern, medical schools nationwide are increasing their efforts to recruit and train premedical students to fill this gap. Those efforts inclu…

SAT-355 Thyrotoxicosis Associated with Leukopenia in Graves' Disease: A Case Report and Review of Medical Management

Article

Disclosure: C. Makhija: None. M. Bhalla: None. S.S. Thangwaritorn: None. Leukopenia is characterized by a low white blood cell count (WBC) and, is an uncommon manifestation of hyperthyroidism associated with Graves’ disease, affecting …

Quantifying Changes in 3D Acetabular Morphology in Normal Hips Based on the Development of Secondary Ossification Centers.

Article

BACKGROUNDAcetabular development in pediatric hips is driven by growth from the triradiate cartilage (TRC) and secondary ossification centers (SOCs) of the os pubis, os ischium, and os ilium. These SOCs appear and fuse at different ages, with sex-sp…

Modified peroxamide-based reactive oxygen species (ROS)-responsive doxorubicin prodrugs.

Article

Reactive oxygen species (ROS) plays a pivotal physiological role in intracellular signaling of any living organism. Due to the elevated levels of ROS in tumor microenvironment than normal tissues, an increasing number of ROS-responsive probes and pr…

The Associations Between Obesity and Deep Vein Thrombosis in Patients With Cardiovascular Disease: A Narrative Review

Article

This article provides an in-depth review of the relationship between obesity and deep vein thrombosis (DVT) in patients with cardiovascular disease (CVD). Our aim is to enhance understanding of the associations between obesity and DVT, particularly …

Finding balance: Offering a systematic method to explore the influence of technology on team-based learning.

Article

INTRODUCTIONTeam-based learning (TBL) is a small group active learning andragogy promoting the development of critical thinking, communication, and teamwork skills. Across higher education, the adoption of educational technology is often driven by m…

Integration of Nutrition Topics in Osteopathic Medical School Curriculum - Shared Experiences

Article

This article was migrated. The article was marked as recommended. A crucial component of osteopathic medicine's philosophy is self-regulation, preventive care, and health maintenance, including a healthy lifestyle. More than half of the osteopathic …