CHSU Discovery

Abstract MicroRNAs (miRNAs) are key regulators of post-transcriptional gene expression in the nervous system, where they fine-tune gene activity. Highly enriched in neural tissue, miRNAs influence neuroplasticity by modulating processes such as neur…

Mucormycosis is an Angioinvasive fungal infection caused by the fungi order Mucorales. It is a rare disease affecting 1.7 people per every 1,000,000 in the general population with an overall all-cause of mortality rate of 54%. We present the case of…

Depressive disorders are common mental health conditions that affects millions of people worldwide and are characterized by persistent feelings of sadness, hopelessness, and a loss of interest in activities that were once enjoyable. Research has sho…

Abstract Severe hyponatremia (serum sodium level ≤ 120 mmol/L) management guidelines recommend administering hypertonic sodium chloride (HTS) to initially raise serum sodium levels by 4-6 mmol/L. ​ While various HTS doses and concentrati…

AbstractThe patient population at United Health Centers (UHC) Bullard in Fresno experiencesbarriers to seeking mental health resources such as lack of awareness regardingavailable resources, cultural stigma, financial constraints, lack of transporta…

Abstract Hepatocellular carcinoma (HCC) is the third largest cause of cancer-induced mortality worldwide. The MYConcogene is a prevalent driver of human neoplasia, including HCC. Immune checkpoint inhibitors have succeeded in treating many MYC-drive…

Abstract Aim Nearly 10% of California’s adult population has diabetes. In California’s Central Valley, patients with T2DM face disproportionate challenges to diabetes management. Lifestyle education and modifications have been shown to l…

Abstract Prostate cancer is both the most frequently diagnosed malignancy among men worldwide and the most significant contributor to cancer-associated mortalities in the United States. Commonly known risk factors include family history,  …

Neuromyelitis Optica Spectrum Disorders (NMOSD) aka’s Devic Disease or Neuromyelitis Optica (NMO) is a rare disease. It has 10x high predilection to female than male, ages 32-41, primarily African American and Afro-Caribbean with diagnosing cr…

Abstract: Introduction/Background: Malignant Mucosal melanoma (MMM) arising from melanocytes in the mucosal linings of the body, is the least common and most aggressive form of melanoma. The Pathogenesis of mucosal melanoma is not well known compare…

Abstract Ischemic stroke leads to motor, sensory, and cognitive impairments that reduce quality of life.​ Neuroplasticity enables the brain to reorganize and form new connections essential for recovery.​ Rehabilitation leverages neuroplasticity, wit…

Abstract Meconium peritonitis is a sterile chemical reaction due to in-utero bowel obstructionand perforation with leakage of meconium into the peritonium.(1) Inflammatoryresponse secondary to the chemical peritonitis could result in ascites, dystro…

Abstract Tricyclic antidepressants (TCAs) are used to treat major depressive disorder by increasing serotonin and norepinephrine levels through reuptake inhibition. This enhances neurotransmitter activity, improving mood and cognitive function. …

Abstract:Introduction: Autoimmune hepatitis is a rare autoimmune liver disease characterized by elevated liver enzymes, hypergammaglobulinemia, and autoantibodies. It predominantly affects young to middle-aged women, but can also occur in the elderl…