CHSU Discovery

Abstract: Caffeine is a widely consumed stimulant present in coffee, tea, chocolate, and energy drinks. Not only does caffeine improve mood and relief from headaches, but also it is linked to reduction of risk strokes, Parkinson's, and Alzheime…

Abstract Food insecurity is a social determinant of health comprised of a hierarchy of four domains: availability, access, utilization, and stability. Reliable access to food is particularly limited in rural areas like south-central Pennsylvania and…

Abstract:A 2020 study conducted in the United Kingdom of 76 general practices, including 622 patients, examined the efficacy of combining self-monitoring blood pressure with guided self-management. Digital intervention provided feedback of blood pre…

Diabetes has been an increasing public health concern. Clinical trials from Community Diabetes Education led by community healthcare workers have been a cost-effective way of reducing diabetes complications in Mexican Americans. Culturally tailored …

Background: 20% of older adults experiencing mental and neurological disorders.During the height of the COVID-19 pandemic and the shelter-in-place orders, loneliness and social isolation were higher than ever before.Depression is commonly underdiagn…

Introduction:Coccidioidomycosis, or Valley Fever, is a fungal infection found in the Southwestern United States (1). It iscaused by inhaling fungal spores and can lead to respiratory illness and potentially fatal complications(2). Purpose: The study…

Total hip arthroplasty (THA) involves the replacement of pathologic hip joints withprosthetic implants to restore functionality and alleviate pain. Current implants forreplacing the acetabulum use a "press-fit" application with no screws; however, i…

Abstract Hepatocellular carcinoma (HCC) is the third largest cause of cancer-induced mortality worldwide. The MYConcogene is a prevalent driver of human neoplasia, including HCC. Immune checkpoint inhibitors have succeeded in treating many MYC-drive…

Abstract This pilot observational study examines the effect of the COVID-19 restrictions, transportation, and healthliteracy (HL) during the pandemic on HbA1c testing rates at a local Federally Qualified Health Center (FQHC). We hypothesize that ide…

Amongst 40% of population with SLE who test positive for Antiphospholipid antibodies (aPL) only 7-15% of the patients develop Antiphospholipid antibody syndrome. Repeat aPL after a duration of 12 or more weeks and lack of continuity of care can some…

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. Incidence rates among individuals under 50 years are rising, which has led to the lowering of the recommended screening age from 50 to 45 years for those at an av…

Abstract:Coccidioidomycosis is endemic in the western hemisphere, commonly occurring through inhalation of arthroconidia. Sixty percent are asymptomatic, while 40% have pneumonia-like symptoms. Extra-thoracic coccidioidomycosis has an overall incide…

Abstract:Introduction and Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe, life-threatening inflammatory disorder, with an estimated annual incidence of 1.5 per million, affecting multiple organ systems and carrying a high risk of m…

Primary brain tumors are considered relatively rare. Most cases of brain tumors consist of metastatic disease from the lung, breast, colon, and kidney. The most common primary brain tumors include meningiomas, glioblastomas, and astrocytomas. Brain …

Abstract: Introduction: Emphysematous gastritis, characterized by air within the stomach wall due to gas-producing organisms, presents with symptoms of abdominal distention, tenderness, and acute abdomen bearing a high mortality rate of 60-80%. Conv…

Abstract Context: Premedical preparatory programs at osteopathic medical schools that recruit students from medically underserved areas (MUAs) may promote interest in practicing osteopathic medicine in underserved areas. In these programs, fostering…

Abstract: Introduction/Background: Malignant Mucosal melanoma (MMM) arising from melanocytes in the mucosal linings of the body, is the least common and most aggressive form of melanoma. The Pathogenesis of mucosal melanoma is not well known compare…

Abstract:  Purpose of Study: The patient, a previously healthy 32-year-old female, initially presented with psychiatric symptoms, including psychosis, agitation, and delusions. Subsequent neurological examination revealed the presence of s…

Abstract This case study focuses on a woman in her late fifties with past medical history of recurrent childhood respiratory and skin infections presenting to the pulmonology clinic with dyspnea and wheezing only partially relieved with inhalers and…

Intro:The Solute Carrier 22 (SLC22) family is perhaps best known as a family of “drug” transporters.OCT1, OAT1, and OAT3 are among the most important multi-specific drug transporters in thebody. The SLC22 family of transporters can be se…