CHSU Discovery

Abstract

Tricyclic antidepressants (TCAs) are used to treat major depressive disorder by increasing serotonin and norepinephrine levels through reuptake inhibition. This enhances neurotransmitter activity, improving mood and cognitive function. TCAs also influence:​ Neuroplasticity – the brain's ability to reorganize and form new neural connections.​ Synaptic plasticity – adaptability of synaptic strength.​Dendritogenesis – the formation of new dendritic branches essential for synaptic communication.​ Imipramine and desipramine are two prototypical TCAs studied for their distinct effects on neuroplasticity and synaptic function.