CHSU Discovery

Background

CRPS is a chronic pain syndrome often triggered by trauma or nerve
injury1.
• Type 2 CRPS involves confirmed nerve damage.
• Symptoms include burning pain, swelling, skin changes, and allodynia.
• CRPS can affect the GI, autonomic, and immune systems2.
• GI symptoms like diarrhea and nausea are common but
underrecognized2.
• MCAS can worsen CRPS through histamine and cytokine release4.
• hEDS contributes to CRPS risk due to tissue fragility and joint
instability.
• MCAS and hEDS may lead to multisystem symptoms in CRPS
patients.
• VAS is often insufficient for capturing complex, fluctuating pain.
• Subjective pain scoring offers a more holistic view of symptom burden.