CHSU Discovery

Hypertriglyceridemia (HTG): triglyceride levels ≥ 150 mg/dL • HTG is associated with an increased risk of atherosclerotic cardiovascular disease and pancreatitis • ~20% acute pancreatitis cases result from severe HTG ( > 500 mg/dL) • HTG-associated acute pancreatitis (HTG-AP) pathophysiology: impaired circulatory flow within pancreatic capillaries due to free fatty acid accumulation • Plasmapheresis effectively reduces triglyceride levels, but is not recommended as a first-line therapy by the Endocrine Society due to its cost and complication risks • Insulin infusions lower triglyceride levels through enhancing the metabolism of chylomicrons and very low-density lipoproteins • Use of insulin infusions in the management of HTG is not standardized • Study purpose: evaluate the safety and efficacy of an insulin infusion order set specifically designed for managing HTG