CHSU Discovery

Abstract:  

NADPH oxidases (NOXs) are an enzyme family that produce reactive oxygen species (ROS) functionally to aid in signaling and other biological processes. The NOX family is comprised of seven isoforms: NOX1, NOX2, NOX3, NOX4, NOX 5, DUOX1, and DUOX2. The NOX enzymes are each distributed throughout different sets of tissues. Dysregulation contributes to an increase in ROS and oxidative damage--correlating with a variety of pathologic conditions such as cardiovascular disease, respiratory disease, and cancers. This paper explores the role of increased NOX expression and dysregulation in disease progression as well as the potential for NOX inhibitors to serve as therapeutic interventions.  

This poster focuses on the NOX family of enzymes. Of note, NOX2 is the most well-studied member of the family owing to its core immunological function. This review will detail other members of this family of enzymes. In this poster we will initially review the biological function of several NOX members including tissue distribution, cellular biology, and associated proteins. We then review specific conditions correlated with NOX dysfunction. Finally, we discuss therapeutic applications and recent trails of NOX family inhibitors.